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Researchers

Ken Cornell

Associate Professor, Chemistry/Biochemistry - Boise State University
kencornell@boisestate.edu • (208) 426-5429

Education

  • Portland VA Medical Center, Post-doctoral, Biochemistry/ Immunology 1997-1998
  • Oregon Health & Sciences University, Ph.D. Biochemistry, 1997
  • Wichita State University, M.S. Microbiology, 1985
  • Oregon State University, B.S. Microbiology, 1983

Teaching Areas

  • Biochemistry

Featured Publications

  • 1. Hefeneider, SH, Bennett, RM, Pham, TQ, Cornell, KA, McCoy, SH, and Heinrich, MC. (1990) Identification of a cell surface DNA receptor association with systemic lupus erythematosus. J. Invest. Derm. 94(6):79s-84s.
  • 2. Bennett, RM, Cornell, KA, Merritt, MJ, Bakke, AC, Hsu, PH, and Hefeneider, SH. (1991) Autoimmunity to a 28-30 kD cell membrane DNA binding protein: occurrence in selected sera from patients with SLE and Mixed Connective Tissue Disease (MCTD). Clin. Exp. Immunol. 86(3): 374-379.
  • 3. Bennett, RM, Cornell, KA, Merritt, MJ, Bakke, AC, Mourich, D, and Hefeneider, SH. (1992) Idiotypic mimicry of a cell surface DNA receptor: evidence for anti-DNA antibodies being a subset of anti-anti-DNA receptor antibodies. Clin. Exp. Immunol. 90: 428-433.
  • 4. Hefeneider, SH, Cornell, KA, Brown, LE, Bakke, AC, McCoy, SH and Bennett, RM. (1992) Nucleosomes and DNA bind to the same cell-surface molecules and induce cytokine production by murine spleen cells. Clin. Immunol. Immunopath. 63(3): 245-251.
  • 5. Winter, RW, Cornell, KA, Johnson, LL, and Riscoe, MK. (1993) Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae. Bioorg. & Med. Chem. Letters 3(10): 2079-2082.
  • 6. Hefeneider, SH, Brown, LE, McCoy, SH, Bakke, AC, Cornell, KA, and Bennett, RM. (1993) Immunization of BALB/c mice with monoclonal anti-DNA antibody induces an anti-idiotypic antibody reactive with a cell-surface DNA binding protein. Autoimmunity 15: 187-194.
  • 7. Winter, RW, Cornell, KA, Johnson, LL, Isabelle, LM, Hinrichs, DJ, and Riscoe, MK. (1995) Hydroxy-anthraquinones as antimalarial agents. Bioorg. & Med. Chem. Letters 5(17): 1927-1932.
  • 8. Winter, RW, Cornell, KA, Johnson, LL, Ignatushchenko, M, Hinrichs, DJ, and Riscoe, MK. (1996) Potentiation of the antimalarial agent Rufigallol. Antimicrobial Agents & Chemo. 40(6): 1408-1411.
  • 9. Cornell, KA, Winter, RW, Tower, PA, and Riscoe, MK. (1996) Affinity purification of 5-methylthioribose kinase and 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae.Biochem J. 317: 285-290.
  • 10. Cornell, KA, Swarts, WE, Barry, RA, and Riscoe, MK. (1996) Characterization of recombinant Escherichia coli 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase: analysis of enzymatic activity and substrate specificity. Biochem. Biophys. Res. Commun. 228: 724-732.
  • 11. Winter, RW, Ignatushchenko, M, Ogundahunsi, OAT, Cornell, KA, Oduola, AD, Hinrichs, DJ, and Riscoe, MK. (1997) Potentiation of an antimalarial oxidant drug. Antimicro. Agents &Chemo. 41(7): 1449-1454.
  • 12. Cornell, KA, and Riscoe, MK (1998) Cloning and expression of Escherichia coli 5’-methylthioadenosine /S-adenosylhomocysteine nucleosidase: identification of the pfs gene product. Biochem. Biophys. Acta, 1396: 8-14.
  • 13. Cornell, KA, Bouwer, HGA, Hinrichs, DJ, and Barry, RA (1999) Genetic immunization of mice against Listeria monocytogenes using plasmid DNA encoding listeriolysin O. J. Immunol., 163: 322-329.
  • 14. Brown, JR, Cornell, KA, and Cook, PW (2000) Adenosine- and Adenine-nucleotide-mediated inhibition of normal and transformed keratinocyte proliferation is dependent upon dipyridamole-sensitive adenosine transport. J. Invest. Derm., 115(5) 849-859.
  • 15. Lee, JE, Cornell, KA, Riscoe, MK, and Howell, PL (2001) The crystal structure of E. coli 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals structural similarity to the purine mucleoside phosphorylases. Structure 9: 941-953.
  • 16. Lee, JE, Cornell, KA, Riscoe, MK, and Howell, PL (2001) Expression, purification, crystallization and preliminary X-ray analysis of E. coli 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Acta crystallographica (D57) 150-152.
  • 17. Winzer, K, Hardie, KR, Burgess, B, Doherty, N, Kirke, D, Holden, MTG, Linforth, R, Cornell, KA, Taylor, AJ, Hill, PJ, Williams, P (2002) LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Microbiology 148: 909-922.
  • 18. Lee, JE, Cornell, KA, Riscoe, MK, and Howell, PL (2003) Structure of E. coli 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into conformational changes required for substrate binding and catalysis. J. Biol. Chem. 278: 8761-8770
  • 19. Hinrichs, DJ, Cornell, KA, Bouwer, HGA, and Barry, RA (2003) Protective immunization of interferon g knockout mice following intramuscular DNA vaccination. Vaccine 21(17-18): 2131-2141
  • 20. Simon, BE, Cornell, KA, Clark, TR, Chou, S, Rosen, HR, and Barry, RA (2003) DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein. Infect. Immun. 71(11): 6372-80.
  • 21. Zhao, G, Wan, W, Mansouri, S, Alfaro, JF, Bassler, BL, Cornell, KA, and Zhou, ZS (2003) Chemical synthesis of S-ribosyl-L-homocysteine and activity assay as a LuxS substrate. Biorg. and Med. Chem. Letts. 13(22): 3897-900.
  • 22. Ku, SY, Yip, P, Cornell, KA, Riscoe, MK, Howell, PL (2004) Crystallization and preliminary X-ray analysis of 5-methylthioribose kinase from Bacillus subtilis and Arabidopsis thaliana. Acta crystallogr.D. Biol Crystallogr. 60(Pt 1):116-9.
  • 23.Lee, JE, Settembre, EC, Cornell, KA, Riscoe, MK, Sufrin, JR, Ealick, SE, Howell, PL (2004) Structural comparison of MTA phosphorylase and MTA/SAH nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 43: 5159-5169.
  • 24. Cook, PW, Brown, JR, Cornell, KA, Pittelkow, MR (2004) Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp Dermatol. 13(6):347-56.
  • 25. Sauter, M, Sára Beszteri, S, Cornell, KA, Rzewuski, G (2004) Functional analysis of methylthioribose kinase genes in plants. Plant Phys. 136: 4061-4071.
  • 26. Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL (2005) Structural rationale for the affinity of PICO-and femtomolar transition state analogues of E. coli 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase. J. Biol Chem. 280(18):18274-82.
  • 27. Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL (2005) Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. J. Mol. Biol. 352(3): 559-574.
  • 28. Lee JE, Luong W, Huang DJ, Cornell KA, Riscoe MK (2005) Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis. Biochemistry 44(33): 11049-11057.
  • 29. Parveen N, Cornell KA, Bono JL, Chamberland C, Rosa P, Leong JM (2006) Bgp, a secreted GAG-binding protein of B. burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect. Immun. 74(5):3016-20.

Awards

  • 1. “DNA Safeguard” (Co-investigator) Dept. of Defense Appropriations grant 11/01/06 – 10/31/07
  • 2.“Development of Non-polar Electrical Field Flow Fractionation for Membrane Protein Purification” (Principle investigator) Boise State University Faculty Research Grant 07/15/06 – 07/14/07
  • 3. “A Preparative Scale Ultracentrifuge for the College of Arts and Sciences” (Principle Investigator). NSF EPSCoR Research Infrastructure Grant/ Boise State University 09/01/06
  • 4.“Development of Novel Antimicrobial Catheters” (Principle Investigator) NIH R43AI061894. 11/01/05 – 4/30/06
  • 5.“Methylthioribose kinase inhibitors as herbicides and anti-senescence agents in plants” (Principle Investigator). USDA (02-0047) 12/02-6/03